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Avoid repeated freezethaw cycles

Prior to this several other anti-obesity drugs had also proven disappointing due to adverse effects such as cardiovascular problems, increased suicidal risk and enhanced drug dependence and abuse (Mller, Blher, Tschp, DiMarchi)

For people with IBS, this raises an important question: what happens when a medication designed to slow gut motility meets an already sensitive gut

For example, GLP-1R in adipocytes can directly regulate apoptosis and preadipocyte proliferation by activating the adenylate cyclase/cyclic adenosine monophosphate (AC/cAMP) signaling pathway and various cell signaling cascades, including extracellular signal-regulated kinase (ERK), protein kinase C (PKC), and protein kinase B (AKT) [41,46]

Most pharmacokinetic studies assessing the brain uptake of incretin mimetics have been conducted in animals, and translating these findings to human subjects and clinical outcomes remains uncertain